HOWELL RESEARCH GROUP

DEPARTMENT OF CHEMISTRY
UNIVERSITY OF CONNECTICUT

PUBLICATIONS

  1. “A Rapid Fluorescence-based Assay for Classification of iNKT Cell Activating Glycolipids," Arora, P.; Venkataswamy, M. M.; Baena, A.; Bricard, G.; Li, Q.; Veerapen, N.; Ndonye, R.; Park, J. -J.; Lee, J. H.; Seo, K. -C.; Howell, A. R.; Chang, Y. -T.; Illarionov, P. A.; Besra, G. S.; Chung, S. -K.; Porcelli, S. A. J. Am. Chem. Soc. 2011, accepted for publication.

  2. "A Molecular Basis for the Exquisite CD1d-restricted Antigen-specificity and Functional Responses of Natural Killer T Cells,” Wun, K. S.; Cameron, G.; Patel, O.; Pang, S. S.; Pellicci, D. G.; Sullivan, L. C.; Keshipeddy, S.; Young, M. H.; Uldrich, A. P.; Thakur, M. S.; Richardson, S. K.; Howell, A. R.; Illarionov, P. A.; Brooks, A. G.; Besra, G. S.; McCluskey, J.; Gapin, L.; Porcelli, S. A.; Godfrey, D. I.; Rossjohn, J. Immunity 2011, asap.

  3. “Mouse and Human iNKT Cell Agonist Beta-Mannosylceramide Reveals a Distinct Mechanism of Tumor Immunity,” O’Konek, J. J.; Illarionov, P.; Khursigara, D. S.; Ambrosino, E.; Izhak, L.; Castillo, B. F. II; Raju, R.; Khalili, M.; Kim, H. -Y.; Howell, A. R.; Besra, G. S.; Porcelli, S. A.; Berzofsky, J. A.; Terabe, M. J. Clin. Invest. 2011, 121, 683-694.

  4. "Alpha-Galactosylceramide Analogs with Weak Agonist Activity for Human iNKT Cells Define New Candidate Anti-inflammatory Agents ,” Bricard, G.; Venkataswamy, M. M.; Yu, K. O. A.; Im, J. S.; Ndonye, R. M.; Howell, A. R.; Veerapen, N.; Iliarionov, P. A.; Besra, G. S.; Li, Q.; Chang, Y.-T.; Porcelli, S. A. PLoS one 2010, 5, e14374.

  5. "Unexpected Cleavage of 2-Azido-2-(hydroxymethyl)oxetanes: Conformation Determines Reaction Pathway?" Farber, E.; Herget, J.; Gascon, J.; Howell, A. R.; J. Org. Chem. 2010, 75, 7565-7572.

  6. "A CD1d-Dependent Antagonist Inhibits the Activation of Invariant NKT Cells and Prevents Development of Allergen-Induced Airway Hyperreactivity," Lombardi, V.; Stock, P.; Singh, A.; Kerzerho, J.; Yang, W.; Sullivan B. A.; Li, X.; Shiratsuchi, T.; Hnatiuk, N.; Howell, A. R.; Yu, K. O. A.; Porcelli, S. A.; Tsuji, M.; Kronenberg, M.; Wilson, B.; Akbari, O.; J. Immunol. 2010, 184, 2107-2115.

  7. "Design and Synthesis of an Activity-Based Probe Template for Protein Kinases," Keshipeddy, S.; Shi, Y.; Hnatiuk, N.; Morton, M.; Yao, X.; Howell, A. R.; Synlett 2010, 7, 1142-1144.

  8. "Adaptability of the Semi-Invariant Natural Killer T-cell Receptor Towards Structurally Diverse CD1d-Restricted Ligands" Joyce, S.; Florence, W. C.; Xia, C.; Gordy, L. E.; Chen, W.; Zhang, Y.; Scott-Browne, J.; Kinjo, Y.; Yu, K. O. A.; Keshipeddy, S.; Pellicci, D. G.; Patel, O.; Kjer-Nielsen, L.; McCluskey, J.; Godfrey, D. I.; Rossjohn, J.; Richardson, S. K.; Porcelli, S. A.; Howell, A. R.; Hayakawa, K.; Gapin, L.; Zajonc, D. M. EMBO J. 2009, 28, 3579-3590.

  9. "Recognition of Lyso-phospholipids by Human Natural Killer T Lymphocytes," Fox, L. M.; Cox, D. G.; Lockridge, J. L.; Wang, X.; Chen, X.; Scharf, L.; Trott, D.; Veerapen, N.; Ndonye, R. M.; Besra, G. S.; Howell, A. R.; Cook, M. E.; Adams, E. J.; Hildebrand, W. H.; Gumperz. J. E. PLoS Biol. 2009, 7, e1000228.

  10. "T Cell Receptor CDR2b and CDR3b Loops Collaborate Functionally to Shape the iNKT Cell Repertoire," Mallevaey, T.; Scott-Browne, J. P.; Matsuda, J. L.; Young, M. H.; Pellicci, D. G.; Patel, O.; Thakur, M.; Kjer-Nielsen, L.; Richardson, S. K.; Cerundolo, V.; Howell, A. R.; McCluskey, J.; Godfrey, D. I.; Rossjohn, J.; Marrack, P.; Gapin, L. Immunity 2009, 31, 60-71.

  11. “Synthesis and Evaluation of 3”- and 4”-Deoxy and -Fluoro Analogs of the Immunostimulatory Glycolipid, KRN7000,” Raju, R.; Castillo, B. F.; Richardson, S. K.; Thakur, M.; Severins, R.; Kronenberg, M.; Howell, A. R. Bioorg. Med. Chem. Lett. 2009, 19, 4122–4125.

  12. “Kinetics and Cellular Site of Glycolipid Loading Control the Outcome of Natural Killer T cell Activation,” Im, J. S.; Arora, P.; Bricard, G.; Molano, A.; Venkataswamy, M. M.; Baine, I.; Jerud, E. S.; Goldberg, M. F.; Baena, A.; Yu, K. O. A.; Ndonye, R. M.; Howell, A. R.; Yuan, W.; Cresswell, P.; Chang, Y. -T.; Illarionov, P. A.; Besra, G. S.; Porcelli, S. A. Immunity 2009, 30, 888-898.

  13. “Synthesis and Evaluation of an Acyl-chain Unsaturated Analog of the Th2 Biasing, Immunostimulatory Glycolipid, OCH,” Velmourougane, G.; Raju, R.; Bricard, G.; Im, J. S.; Besra, G. S.; Porcelli, S. A.; Howell, A. R. Bioorg. Med. Chem. Lett. 2009, 19, 3386-3388.

  14. "Cross Metathesis of alpha-Methylene-beta-lactams: The First Tetrasubstituted Alkenes by CM,” Liang, Y.; Raju, R.; Taylor, C. D.; Le, T.; Howell, A. R. Tetrahedron Lett. 2009, 50, 1020-1022.

  15. "Natural Killer T cell Autoreactivity Leads to a Specialized Activation State,"Wang, X.;Chen, X.; Rodenkirch, L.; Simonson, W.; Wernimont, S.; Ndonye, R. M.; Veerapen, N.; Gibson, D.; Howell, A. R.; Besra, G. S.; Painter, G. F.;Huttenlocher, A.; Gumprez, J. E. Blood, 2008, 112, 4128-4138.

  16. “Regulatory Roles for NKT Cell Ligands in Environmentally Induced Autoimmunity,” Vas, J.; Mattner, J.; Richardson, S. K.; Ndonye, R; Gaughan, J. P.; Howell, A. R.; Monestier, M. J. Immunol. 2008, 181, 6779-6788

  17. "Natural Sphingomonas Glycolipids Vary Greatly in Their Ability to Activate Natural Killer T Cells" Kinjo, Y.; Pei, B.; Bufali, S.; Raju, R.; Richardson, S. K.; Imamura, M.; Fujio, M.; Wu, D.; Khurana, A.; Kawahara, K.; Wong, C.; Howell, A. R.; Seeberger, P. H.; Kronenberg, M. Chemistry & Biology, 2008, 15, 654-664

  18. "A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR," Wun, K. S.; Borg, N. A.; Kjer-Nielsen, L.; Beddoe, T.; Koh, R.; Richardson, S. K.; Thakur, M.; Howell, A. R.; Scott-Browne, J. P.; Gapin, L.; Godfrey, D. I.; McCluskey, J.; Rossjohn, J. J. Exp. Med. 2008, 205, 939-949

  19. “Alpha-S-GalCer: Synthesis and Evaluation for iNKT Cell Stimulation,” Blauvelt, M.; Khalili, M.; Jaung, W.; Wilson, S. B.; Paulsen, J.; Anderson, A. C.; Howell, A. R. Bioorg. Med. Chem. Lett. 2008, 18, 6374-6376

  20. “Synthesis of epi-Oxetin via a Serine Derived 2-Methyleneoxetane,” Blauvelt, M.; Howell, A. R. J. Org. Chem. 2008, 73, 517-521

  21. “3-Silyloxytetrahydrofurans via Sulfoxonium Ylide Reactions with alpha- Silyloxyepoxides,” Sabila, P. S.; Liang, Y.; Howell, A. R. Tetrahedron Lett. 2007, 48, 8356-8359

  22. “2-Alkylidene Oxetanes by Stereospecific Elimination of Mesylates,” Sabila, P. S.; Howell, A. R. Tetrahedron Lett. 2007, 48, 8353-8355

  23. “Synthesis and Reactions of 2-Alkylidene Thiiranes and Thietanes,” Richardson, S. K.; Howell, A. R. Synthesis, 2007, 2755-2778.

  24. “Rapid Identification of Immunostimulatory alpha- Galactosylceramides Using Synthetic Combinatorial Libraries,” Li, Q., Ndonye, R. M.; Illarianov, P. A.; Yu, K. O. A.; Jerud, E. S.; Porcelli, S. A.; Besra, G. S.; Chang, Y.-T.; Howell, A. R. J. Combi. Chem. 2007, 9, 1084-1093

  25. “Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d,” Yu, K. O. A.; Im, J. S.; Illarionov, P. A.; Ndonye, R. M.; Howell, A. R.; Besra, G. S.; Porcelli, S. A. J. Immunological Meth. 2007, 323, 11-23.

  26. “Cross Metathesis of alpha- Methylene Lactones II: gamma and delta- Lactones,” Raju, R.; Allen, L. J.; Le, T.; Taylor, C. D.; Howell, A. R. Org. Lett. 2007, 9, 1699-1701.

  27. “Improved Outcomes in NOD Mice Treated with a Novel Th2 Cytokine Biasing NKT Cell Activator,” Forestier, C.; Takaki, T.; Molano, A.; Im, J. S.; Blaine, I.; Jerud, E. S.; Illarionov, P.; Ndonye, R.; Howell, A. R.; Santamaria, P.; Besra, G.; DiLorenzo, T. P.; Porcelli, S. A.  J. Immun. 2007, 178, 1415-1425.

  28. “Cross Metathesis with Strained Exocyclic Enones: 3-Alkylideneoxetane-2-ones from 3-Methyleneoxetan-2-ones,” Raju, R.; Howell, A. R. Org. Lett. 2006, 8, 2139-2141.

  29. “T-bet Concomitantly Controls Migration, Survival and Effector Functions During the Development of Va14i NKT Cells,” Matsuda, J. L.; Zhang, Q.; Ndonye, R.; Richardson, S. K.; Howell, A. R.; Gapin, L. Blood 2006, 107, 2797-2805.

  30. “Synthesis and Properties of psico-Nucleosides,” Richardson, S. K.; Howell, A. R.; Taboada, R.  Org. Prep. Proc. Int. 2006, 38, 101-176.

  31. “Synthesis and Evaluation of Sphinganine Analogues of KRN7000 and OCH,” Ndonye, R. M.; Izmirian, D. P.; Dunn, M. F.; Yu, K. O. A.; Porcelli, S. A.; Khurana, A.; Kronenberg, M.; Richardson, S. K.; Howell, A. R. J. Org. Chem. 2005, 70, 10260-10270.

  32. “Multiphoton Excited Fabrication of Collagen Matrices Crosslinked by a Modified Benzophenone Dimer: Bioactivity and Enzymatic Degradation,” Basu, S.; Cunningham, L. P.; Pins, G. D.; Bush, K. A.; Taboada, R.; Howell, A. R.; Wang, J.; Campagnola, P. J. Biomacromolecules, 2005, 6, 1465-1474.

  33. "Approaches to the preparation of sphinganines." Howell, A. R.; So, R. C.; Richardson, S. K. Tetrahedron, 2004, 60, 11327-11347.


  34. "Straightforward Synthesis of Sphinganines via a Serine-derived Weinreb Amide." So, R. C.; Ndonye, R.; Izmirian, D. P.; Richardson, S. K.; Guerrera, R. L.; Howell, A. R. J. Org. Chem., 2004, 69, 3233-3235.

  35. "Unusual, Strained Heterocyles: 3-Alkylidene-2-methyleneoxetanes from Morita-Baylis-Hillman-type Adducts," Martínez, I; Andrews, A. E.; Emch, J. D.; Ndakala, A. J.;Wang, J.; Howell, A. R. Org. Lett., 2003, 5, 399-402.

  36. "Directed Ring-opening of 1,5-Dioxaspiro[3.2]hexanes: Selective Formation of 2,2-Disubstituted Oxetanes," Taboada, R.; Ordonio, G. G.; Ndakala, A. J.; Howell, A. R.; Rablen, P. R. J. Org. Chem., 2003, 68, 1480-1488.

  37. "The Role of Lattice Oxygen in Selective Benzyl Alcohol Oxidation Using OMS-2 Catalyst: A Kinetic and Isotope-Labeling Study, " Makwana, V. D.; Son, Y.-C.; Howell, A. R.; Suib, S. L. Journal of Catalysis  2002,  210,  46-52.

  38. "New Photoactivators for Multi-photon Excited 3 Dimensional Sub-micron Crosslinking of Proteins: Bovine Serum Albumin and Type 1 Collagen," Pitts, J. D. Howell, A. R.; Taboada, R.; Banerjee, I.; Wang, J.; Goodman, S. L.; Campagnola, P. J. Photochemistry and Photobiology, 2002, 76, 135-144.

  39. "Ring Opening Reactions of 2-Methyleneoxetanes," Wang, Y.; Bekolo, H.; Howell, A. R. Tetrahedron, 2002, 58, 7101-7107.

  40. Synthesis of (D)-erythro-Dihydrosphingosine and (D)-xylo-Phytosphingosine from a Serine-derived 1,5-Dioxaspiro[3.2]hexane Template," Ndakala, A. J.; Hashemzadeh, M.; So, R. C.; Howell, A. R., Org.Lett. 2002, 4, 1719-1722.

  41. "The Preparation and Biological Significance of Phytosphingosines," Howell, A. R.; Ndakala, A. J. Current Organic Chemistry 2002, 6, 365-391.

  42. "Preparation and Reactions of 4-Oxaspiro[2.3]hexanes," Bekolo, H.; Howell, A. R. New J. Chem. 2001, 25, 673-675.

  43. "Efficient, Catalytic, Aerobic Oxidation of Alcohols with Octahedral Molecular Sieves," Son, Y.-C.; Makwana, V. D.; Howell, A. R.; Suib, S. L. Angew. Chem. Int. Ed. 2001, 40, 4280-4283.

  44. "The Reaction of Dimethyltitanocene with N-Substituted-beta-Lactams," Martinez, I; Howell, A. R. Tetrahedron Lett. 2000, 41, 5607-5611.

  45. "An Unusual and Efficient Reaction of 2-Methylene-3-phenyloxetane in the Presence of Lithium and DTBB in THF," Hashemzadeh, M.; Howell, A. R. Tetrahedron Lett. 2000, 41, 1859-1862.

  46. “Reductive Cleavage of 2-Methyleneoxetanes with Lithium and 4,4’-di-tert-Butylbiphenyl,” Hashemzadeh, M.; Howell, A. R. Tetrahedron Lett. 2000, 41, 1855-1858.

  47. "3-Dimensional Submicron Polymerization of Acrylamide by Multiphoton Excitation of Xanthene Dyes," Campagnola, P. J.; Delguidice, D. M.; Epling, G. A.; Hoffacker, K. D.; Howell, A. R.; Goodman, S. L. Macromolecules 2000, 33, 1511-1513.

  48. "Preparation and Properties of 2-Methyleneoxetanes," Dollinger L. M.; Ndakala A. J.; Hashemzadeh M.; Wang G.; Wang Y.; Martinez I.; Arcari J. T.; Galluzzo D. J.; Howell, A. R.; Rheingold, A. L.; Figuero, J. S. J. Org. Chem., 1999, 64, 7074-7080.

  49. "Ring-opening of 1,5-Dioxaspiro[3.2]hexanes: Preparation of alpha-Functionalized-beta'-hydroxy Ketones of 2,2-Disubstituted Oxetanes," Ndakala, A. J.; Howell, A. R. Org. Lett. 1999, 1, 825-827.

  50. "1-Iodomethy-3,4-diphenyl-2,6-dioxabicyclo[2.2.0]hexane: The First Example of a [2.2.0] Fused Ketal," Wang, G.; Wang, Y.; Arcari, J. T.; Howell, A. R.; Rheingold, A. L.; Concolino, T. Tetrahedron Lett. 1999, 40, 7051-7053.

  51. "An Unanticipated Ring-Opening of 2-Methyleneoxetanes: A Fundamentally New Approach to the Preparation of Homopropargylic Alcohols," Dollinger, L. M.; Howell, A. R. J. Org. Chem. 1998, 63, 6782-6783.

  52. "The First General Synthesis of 1,5-Dioxaspiro[3.2]hexanes," Ndakala, A. J.; Howell, A. R. J. Org. Chem. 1998, 63, 6098-6099.

  53. "A 2-Methyleneoxetane Analog of Orlistat Demonstrating Inhibition of Porcine Pancreatic Lipase," Dollinger, L. M.; Howell, A. R. Bioorg. and Med. Chem. Lett. 1998, 8, 977-978.

  54. "2-Alkylidene Oxetanes: An Investigation of the Paterno-Buchi Reaction between Aliphatic Aldehydes and Allenes," Howell, A. R.; Fan, R.; Truong, A. Tetrahedron Lett. 1996, 37, 8651-8654.

  55. "A Versatile Preparation of 2-Methyleneoxetanes," Dollinger, L. M.; Howell, A. R. J. Org. Chem. 1996, 61, 7248-7249.

  56. "Saturated and Unsaturated Hydrocarbons," Howell, A. R. and Keeling, S. P. in General and Synthetic Methods; Pattenden, G., Ed.; The Royal Society of Chemistry: Cambridge, 1993; Vol. 15, pp 1-31.

  57. "Saturated and Unsaturated Hydrocarbons," Howell, A. R. in General and Synthetic Methods; Pattenden, G., Ed.; The Royal Society of Chemistry: Cambridge, 1992; Vol. 14, pp 1-25.

  58. "Saturated and Unsaturated Hydrocarbons," Howell, A. R. in General and Synthetic Methods; Pattenden, G., Ed.; The Royal Society of Chemistry: Cambridge, 1992; Vol. 13, pp 1-32.

  59. "Synthesis and Binding Activity of 4-Azanicotine Analogues," Smith, W. T.; Howell, A. R.; Martin, W. R.; Sloan, J. W. J. Het. Chem. 1991, 28, 1147-1151.

  60. "Hydrocobaltation Reactions of 1,3-Dienes. Regioselective Hydroxylation of Myrcene to Geraniol and (+)-Linalool via Allylcobaloxime Intermediates," Howell, A. R.; Pattenden, G. J. Chem. Soc. Perkin Trans. I 1990, 2715-2720.

  61. "Cobalt-Mediated Intermolecular Radical Addition to Carbon-to-Carbon Double Bonds Leading to New Functionalized Alkenes," Bhandal, H.; Howell, A. R.; Patel, V. F.; Pattenden, G. J. Chem. Soc. Perkin Trans. I 1990, 2709-2714.

  62. "Regioselective Hydroxylations of 1,3-Dienes via Hydrocobaltation Reactions. Facile Conversion of Myrcene to Geraniol and to (+)-Linalool," Howell, A. R.; Pattenden, G. J. Chem. Soc., Chem. Commun. 1990, 103-104.

  63. "The Application of Chloromethylaluminum 2-(2-Propenyl)anilide in the Conversion of gamma- and delta-Lactones into Protected Hydroxyacids," Barrett, A. G. M.; Bezhuidenhoudt, B. C. B.; Dhanak, D.; Gasiecki, A. F.; Howell, A. R.; Lee, A.; Russell, M. A. J. Org. Chem. 1989, 54, 3321-3324.

  64. "Redox Glycosidation via Thionoester Intermediates," Barrett, A. G. M.; Bezhuidenhoudt, B. C. B.; Howell, A. R.; Russell, M. A. J. Org. Chem. 1989, 54, 2275-2277.

  65. "Redox Glycosidation: A Novel Approach to Disaccharide Synthesis," Barrett, A. G. M.; Bezhuidenhoudt, B. C. B.; Gasiecki, A. F.; Howell, A. R.; Russell, M. A.; J. Am. Chem. Soc. 1989, 111, 1392-1396.

  66. "Stereospecificity of 2-Methylpiperidine Binding to a Nicotinic Up-Regulatory Site in the Rat Brain P2 Preparation," Sloan, J. W.; Martin, W. R.; Hook, R.; Bostwick, M.; Howell, A. R.; Smith, W. T. Life Sciences 1985, 37, 1367-1372.